منابع مشابه
The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology
The receptors and ligands in this superfamily have unique structural attributes that couple them directly to signaling pathways for cell proliferation, survival, and differentiation. Thus, they have assumed prominent roles in the generation of tissues and transient microen-capabilities are crucial in coordinating the proliferation and protective functions of pathogen-reactive cells. Here, we re...
متن کاملStructural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease.
Members of the TNF receptor superfamily are type I membrane glycoproteins with limited homology (overall homologies: 25%-30%) in the extracellular domain containing variable numbers of cysteine-rich repeats. In contrast, the TNF ligand superfamily members (with the exception of LT-alpha) are type II membrane glycoproteins with limited homology to TNF (overall homologies: 20%) in the extracellul...
متن کاملCommon Gene Variants in the Tumor Necrosis Factor (TNF) and TNF Receptor Superfamilies and NF-kB Transcription Factors and Non-Hodgkin Lymphoma Risk
BACKGROUND A promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased non-Hodgkin lymphoma (NHL) risk. The protein product, TNF-alpha, activates the nuclear factor kappa beta (NF-kappaB) transcription factor, and is critical for inflammatory and apoptotic responses in cancer progression. We hypothesized that the TNF and NF-kapp...
متن کاملCardiac glycosides inhibit TNF- NF- B signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor
*Department of Anatomy, Physiology, and Genetics and Institute for Molecular Medicine, Uniformed Services University School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; †Cancer and Cell Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and §Protein Expression Laboratory, National Cancer Institute SAIC, Nationa...
متن کاملInteraction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI
BLyS (also called TALL-1, THANK, or BAFF) [1] [2] [3] [4] is a member of the tumor necrosis factor (TNF) gene family that stimulates proliferation and immunoglobulin production by B cells. BLyS interacts with the TNF receptor (TNFR) homologue TACI (transmembrane activator and CAML-interactor) [5], and treatment of mice with a TACI-Fc fusion protein abolishes germinal center formation after anti...
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ژورنال
عنوان ژورنال: Cell
سال: 2001
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(01)00237-9